In the above follow-up analysis it was strange that magnesium lost it’s statistically significant effect with Low-T symptoms compared to the initial trial. This is contradictory to mounds of medical literature. Seasonally, blood levels of Vitamin D fluctuate and the effect on free testosterone, but not total testosterone, follows (1). The correlation weakens below statistical significance when blood levels are deficient / insufficient (~20 ng/ml)(2), but can be observed once levels increase to ~40 ng/ml)(3). I wondered if there was a similar quartile-type effect for Magnesium. However, I recalled that there are significant variances in the bioavailability of different forms of magnesium (4, 5). During the pilot I was getting a combination of magnesium -oxide, -malate, and -glycinate; the later two coming from a independent supplement and Redmond Re-Lyte and having very good bioavailability. Magnesium oxide? Not so good, in fact, relatively poor bioavailability. What type of magnesium is used in Animal STAK and PM? Magnesium oxide. I’m not sure how the exact percentages turn out, but if some estimates of glycinate and malate being 30x more bioavailable than oxide (6), it would make a huge difference.
In the above follow-up analysis it was strange that magnesium lost it’s statistically significant effect with Low-T symptoms compared to the initial trial. This is contradictory to mounds of medical literature. Seasonally, blood levels of Vitamin D fluctuate and the effect on free testosterone, but not total testosterone, follows (1). The correlation weakens below statistical significance when blood levels are deficient / insufficient (~20 ng/ml)(2), but can be observed once levels increase to ~40 ng/ml)(3). I wondered if there was a similar quartile-type effect for Magnesium. However, I recalled that there are significant variances in the bioavailability of different forms of magnesium (4, 5). During the pilot I was getting a combination of magnesium -oxide, -malate, and -glycinate; the later two coming from a independent supplement and Redmond Re-Lyte and having very good bioavailability. Magnesium oxide? Not so good, in fact, relatively poor bioavailability. What type of magnesium is used in Animal STAK and PM? Magnesium oxide. I’m not sure how the exact percentages turn out, but if some estimates of glycinate and malate being 30x more bioavailable than oxide (6), it would make a huge difference.
1) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650484/
2) https://www.nature.com/articles/s41598-021-99571-8
3) https://www.thieme-connect.com/products/ejournals/html/10.1055/s-0030-1269854
4) https://link.springer.com/article/10.1007/s12011-018-1351-9
5) https://pubmed.ncbi.nlm.nih.gov/2407766/
6) https://naturalcalm.ca/wp-content/uploads/2014/11/Crisafi-Bioavailability-1.jpg